Tag: medicine (Page 1 of 2)

THE LIVING MEDICINE: HOW A LIFESAVING CURE WAS NEARLY LOST by Lina Zeldovich

October 22, 2024 / Kyle Wendy Skultety / 0 Comments

The dramatic, tragic, long-suppressed story of a forgotten and life-saving cure, and the scientists who discovered and are now reviving it
First discovered in 1917, bacteriophages—or “phages”—are living viruses that devour bacteria. Ubiquitous in the environment, they are found in water, soil, inside plants and animals, and in the human body. When phages were first recognized as medicines, their promise seemed limitless. Grown by research scientists and physicians in France, the Soviet Union, and elsewhere to target specific bacteria, they cured cholera, dysentery, bubonic plague, and other deadly infectious diseases. But after Stalin’s brutal purges and the rise of antibiotics, phage therapy declined and nearly was lost to history—until today.
In The Living Medicine, acclaimed science journalist Lina Zeldovich reveals the remarkable history of phages, told through the lives of the French, Soviet, and American scientists who discovered, developed, and are reviving this unique cure for seemingly intractable diseases. Ranging from Paris to Soviet Georgia to Egypt, India, South Africa, remote islands in the Far East, and America, The Living Medicine shows how phages once saved tens of thousands of lives. Today, with our antibiotic shield collapsing, Zeldovich demonstrates how phages are making our food safe and, in cases of dire emergency, rescuing people from the brink of death. They may be humanity’s best defense against the pandemics to come.
Filled with adventure, human ambition, tragedy, technology, irrepressible scientists and the excitement of their innovation, The Living Medicine offers a vision of how our future may be saved by knowledge from the past.

Thanks to NetGalley and the publisher for this review copy!

Lina Zeldovich’s book, The Living Medicine: How a Lifesaving Cure Was Nearly Lost—and Why It Will Rescue Us When Antibiotics Fail, explores the world of bacteriophages, or phages. These are viruses that specifically infect and kill bacteria, offering a potential solution to the growing crisis of antibiotic resistance.

The book delves into the tumultuous history of phages, from their discovery in 1917 to their near obscurity as antibiotics took center stage in the mid-20th century. Zeldovich explores the reasons behind this shift, including the ease of production, the use of antibiotics compared to phages, and the rise of powerful pharmaceutical companies.

However, with the growing problem of antibiotic-resistant bacteria, phages are re-emerging as a potential weapon in our fight against infectious diseases. The book examines the current research and development efforts around phage therapy, highlighting its potential to combat a wide range of infections.

As antibiotic resistance escalates into a global health crisis, Zeldovich’s work becomes both timely and essential, shedding light on an ancient remedy that may hold the key to our future.

Zeldovich’s storytelling is engaging and accessible, skillfully blending rigorous scientific detail with personal narratives and historical context. She delves into the lives of pioneering scientists who first discovered and utilized phages, such as Félix d’Hérelle and George Eliava, and navigates through the complex socio-political landscapes that influenced their work.

She also provides a detailed account of the geopolitical dynamics that influenced medical research, especially during the Cold War era. In the West, antibiotics became the standard treatment for bacterial infections, leading to the neglect of phage therapy. Meanwhile, in places like Georgia, phage research flourished, resulting in a rich repository of knowledge and experience that has now become invaluable as the world faces the looming crisis of antibiotic resistance.

The author’s ability to weave together historical accounts and scientific explanations makes for a compelling and thought-provoking read. She also adds anecdotes and case studies, illustrating the profound impact of phage therapy on individuals who had exhausted all other medical options. These stories not only humanize the science but also serve as powerful testimonials to the efficacy of phages.

Her personal connection to the topic adds a rich layer to the narrative. Zeldovich draws on her family’s experiences in the Soviet Union, where phage therapy was a common and successful practice. This intimate frame of reference enriches the book, providing a unique perspective on how cultural and political factors shape scientific advancements and healthcare practices.

Zeldovich also explores the innovative research and technological advancements that are propelling phages back into the spotlight. She discusses the potential of genetic engineering to enhance phage efficacy and the promise of personalized medicine tailored to individual patients’ infections. The book builds a compelling argument for why phages should be integrated into the mainstream medical arsenal, especially as the pipeline for new antibiotics dries up. The author also emphasizes the global implications of antibiotic resistance and the need for international collaboration in combating bacterial infections. She highlights how phages offer a ray of hope not only for wealthy nations grappling with antibiotic resistance but also for low-resource settings where access to antibiotics is limited.

Strengths:

THE LIVING MEDICINE tackles a critical issue in public health: antibiotic resistance. As antibiotics become less effective, phages offer a promising alternative. The book also provides a historical perspective on phage therapy, explaining its decline and resurgence.

The narrative is enriched with vivid descriptions and compelling characters, from passionate scientists to desperate patients, which keeps the reader invested throughout.

Concerns:

The book focuses heavily on the potential of phages, with less exploration of the current challenges in bringing phage therapy to mainstream medicine. While the book avoids overly technical jargon, there are sections that might be challenging for readers unfamiliar with scientific concepts. At times, the story jumps from one focus to another, making it sometimes hard to follow the narrative.

While THE LIVING MEDICINE is largely an optimistic account of phages’ potential, Zeldovich does not shy away from discussing the challenges. She addresses the regulatory hurdles, the need for rigorous clinical trials, and the skepticism within the medical community. However, some readers may find the book’s enthusiasm for phages occasionally overshadows these critical perspectives.

This book is a well-researched and informative book that sheds light on a promising area of medical research. It offers a compelling look at phages and their potential to revolutionize how we treat infectious diseases. It is important to note that phage therapy is still in its preliminary stages of development, and more research is needed to determine its efficacy and safety for widespread use. The book does seem to be grounded in scientific research, making the potential of phage therapy seem authentic. To me, it seems like it was written with a scientific background in mind. To that end, this book is highly recommended for medical professionals, microbiologists, and anyone interested in the evolving landscape of healthcare. It also serves as a valuable resource for policy makers and educators looking to understand and address the challenges posed by antibiotic resistance. Zeldovich’s work serves as both a wakeup call and a beacon of hope. This book not only informs but also inspires, making a compelling case for the revival of phage therapy in modern medicine.

Want your own copy? You can pick it up here.

SPIT AND POLISH by D.A. Brown

March 5, 2024 / Kyle Wendy Skultety / 0 Comments

Ruth was delighted when she was accepted into the nursing school at Kingston General Hospital. But she didn’t realize how challenging it would be. She quickly finds her skills aren’t up to snuff and is sent to build them up as an aide at the local tuberculosis sanitarium.
It’s 1946, and when Ruth arrives, she is immediately surrounded by crowds of wounded and infected soldiers, women, and children.
Ruth must find her way among the dying, depressed, and too-friendly patients, managing demanding doctors and a jealous mentor, without being sent home or infected. Can she impress her seniors and be readmitted to the nursing program she so wants?

Thanks to LibraryThing , author DA Brown, and Somewhat Grumpy Press for this advanced reviewer’s copy!

SPIT AND POLISH is a captivating historical fiction novel that transports readers to Canada in 1946, where aspiring nurse Ruth dreams of escaping her small-town life and making a difference. Accepted into Kingston General Hospital’s nursing school, her initial excitement crumbles as she struggles with the demanding coursework. Sent to gain experience at a local tuberculosis sanatorium, Ruth is confronted with the harsh realities of illness, death, and prejudice. Surrounded by wounded soldiers, desperate families, and a complex medical environment, she must navigate challenges while honing her skills. Ruth needs to find her strength, compassion, and the resilience to succeed.

The sanatorium, teeming with wounded soldiers and civilians battling the debilitating disease, paints a stark picture of the era’s healthcare realities. The facility fairly overflows with wounded soldiers, women, and children battling the debilitating disease. Ruth grapples with the emotional and physical demands of caring for, and witnessing firsthand, the suffering and resilience of her patients. Ruth must also navigate navigate dormitory life, avoid flirting soldiers, and handle the draining emotional complexities of her family back home. The author skillfully portrays the harsh realities of the medical setting, balancing it with moments of tenderness and compassion. It is easy to empathize with Ruth’s internal struggles as she confronts her own limitations and prejudices. Her journey is one of personal and professional development, and it is satisfying to see her initial naiveté transform into empathy, strength, and self-assuredness as she faces challenges head-on.

Brown immerses the reader in the post-war atmosphere of Canada, capturing the social anxieties, medical advancements (and limitations), and evolving societal roles of women. The struggles of returning soldiers and the stigma surrounding tuberculosis are woven seamlessly into the narrative.

Ruth’s growth is relatable and engaging, and the supporting cast, from other nursing students to her domineering father, adds depth and nuance. The initial chapters do move a bit slowly as the setting and characters are established. I would have liked to see some of the secondary characters (such as Patricia, Mrs. Graham, and Mary) fleshed out some more. This information might have given some more backstory and understanding of their behavioral quirks and motivation.

One thing that was a bit jarring to me were the short paragraphs of medical notes that began each chapter. One was a quote from 1947, quite a few were from Florence Nightingale’s NOTES ON NURSING, and there was one from 2018 quite early on in the book. While I appreciated the “insider information”, I spent a few minutes trying to figure out if the quote was supposed to reflect the tone of the chapter or not. Some were relevant, while others seemed random to me. I did like the idea of headers to each chapter, but I think they would work a lot better if the words tied in with each chapter’s vignette. Another option would be to let the reader know that the paragraphs at the beginning of each chapter are taken from either various authors who are sharing their thoughts on nursing, or excerpts from textbooks that will give the reader background on how TB was treated back then, etc. That would set an expectation for the reader, allowing them to absorb the information, then move seamlessly into the storyline.

SPIT AND POLISH offers a captivating journey through a unique historical setting. Brown’s well-researched narrative sheds light on the challenges and triumphs of mid-century healthcare, while Ruth’s personal growth resonates with themes of ambition and compassion. The novel delves into the emotional toll of caring for the sick and dying, yet the harsh realities of the sanatorium are balanced with moments of tenderness and hope, creating a nuanced portrayal of human resilience. Throughout the book, the importance of human connection in the face of adversity is underscored – a lesson we can all learn from in today’s world.

Readers interested in historical fiction with strong female protagonists and a touch of medical drama will find this book satisfying. One caveat: be aware of the potential for emotional intensity due to the setting and subject matter.

Want your own copy? You can pick it up here.

TO CURE OR KILL by Michael Young

December 19, 2023 / Kyle Wendy Skultety / 0 Comments

This is a frightening story describing the scientific discovery of a new cancer medication, and the greed and quest for wealth within the pharmaceutical industry. The book delves into the world of scientific development, executive entitlement, and the ruthless efforts to obtain a needed molecular synthesis protocol to advance a new drug. At the end of the novel, the reader will need to ask themselves the underlying question: Is this story really fiction?

Thanks to Reedsy Discovery for this review copy!

In this frightening novel, author Michael Young delves into the dark side of the pharmaceutical industry, where greed and ambition clash with the pursuit of life-saving cures. The story revolves around a groundbreaking discovery of a new cancer-preventing drug and the ruthless individuals who will stop at nothing to exploit it for their own gain. The captivating narrative weaves together scientific intrigue, corporate espionage, and moral quandaries, keeping the reader interested until the very end. The novel’s exploration of the ethical boundaries of scientific research is particularly thought-provoking, raising questions about the balance between profit and human health.

The characters are complex and believable, making you care about their fate. Most of the scientists in this book are created as sympathetic characters (rather than science nerds), and the bad guys are so easy to hate! The author has done a thorough job of creating arrogant, narcissistic criminals, and I was impressed at how he was able to create a plausible story line that delved into the mind of the villains as they planned their heinous actions.

The novel is suspenseful, with plenty of twists and turns to keep you guessing. I also appreciated the accurate medical details: as a physician, Young clearly has a deep understanding of the medical field, which adds to the realism of the story. It is detailed yet easy for the layman to understand. These details may also serve to educate the reader about DNA, , mRNA, how new drugs are created, and medical ethics. There are also extensive descriptions of various poisons and how to use them for nefarious purposes.

One of the author’s strengths is the way he uses adjectives to create a picture. I particularly liked the description of the inside of a character’s home: “Burksdale made a final look around the rather boring, sullen, apartment…”. Another few sentences of note: “With his good looks, self-confidence, and obvious intelligence, Bob could walk into any room and light it up. The women adored him, and the men wanted to be him.”

I also learned some more about company security. We are all subject to phishing and identity theft, and I liked how the tone of chapter 9 was set by chapter 8’s discussing the internet of things and how hackers operate.

This book made me think about medical ethics and corporate greed. The drug companies in the United States are at times both helpful and a hindrance. Lifesaving drugs are created, yet they are ridiculously overpriced, and people may have to choose between food on the table or the medication that makes their quality of life better. It is also very frightening to consider that corporate espionage goes on every day, and we may never find out about it.

Some things I disliked about the book were: simple editing errors regarding spelling (pored over, NOT poured over!) and the author’s excessive use of italics. He used them in many instances where they were not needed. For example: italics are used for all company names (Harris Therapeutics) and websites (Google, Facebook). This became jarring to me, as I normally associate italics being used for emphasis, not to discern a company name or website, etc. Eventually I got italics fatigue and viewed it all like the boy crying wolf.

Another unpleasant idiosyncrasy I noted: the verb tenses were often not compatible with each other within the same sentence. For example, on page 69 the sentence moves from past tense to present: “…Burksdale WAS able to assemble a list….it IS frightening how much personal information IS available online…” And again, from page 73: “Traffic on the expressway CAN BE brutal during rush hour, and getting off late WOULD BE a miserable waste of time”. It was as if the author was writing an aside to the reader to make a point of explaining something. This too, became grating to me, as the English major in me cringed every time I came upon it. It took me away from being absorbed in the story to shuddering and replacing the verb tense in my mind. I have not read any other of Young’s books, so I have no way of knowing if this is a one-off in this particular book, or if that is his true writing style.

One final note: I thought the ending was a bit abrupt. I would have liked to see a little more detail about some of the characters and how their lives were affected.

In Summary: TO CURE OR KILL is a thrilling tale of greed, ambition, and the pursuit of scientific breakthroughs, with a cautionary message about the potential dangers of unchecked ambition. It is also a timely and relevant novel that sheds light on the often-hidden world of pharmaceutical research. The novel explores important themes such as the ethics of scientific research, the greed of corporations, and the power of hope. The plot is a blend of fiction and reality, and the author challenges the reader to question whether such a story could happen.

This book is a must-read for anyone interested in the intersection of medicine, business, and ethics. Fans of medical thrillers and suspenseful fiction will also enjoy this book. I recommend this book to anyone who enjoys reading the works of Robin Cook, Michael Palmer, and Sandeep Jauhar.

Want your own copy? You can pick it up here.

RANDOM ACTS OF MEDICINE by Anupam B. Jena & Christopher Worsham

August 15, 2023 / Kyle Wendy Skultety / 0 Comments

A groundbreaking book at the intersection of health and economics, revealing the hidden side of medicine and how unexpected—but predictable—events can profoundly affect our health. Why do kids born in the summer get diagnosed more often with A.D.H.D.? How are marathons harmful for your health, even when you’re not running? What do surgeons and salesmen have in common? Which annual event made people 30 percent more likely to get COVID-19?
As a University of Chicago–trained economist and Harvard medical school professor and doctor, Anupam Jena is uniquely equipped to answer these questions. And as a critical care doctor at Massachusetts General who researches health care policy, Christopher Worsham confronts their impact on the hospital’s sickest patients. In this singular work of science and medicine, Jena and Worsham show us how medicine really works, and its effect on all of us.

Relying on ingeniously devised natural experiments—random events that unknowingly turn us into experimental subjects—Jena and Worsham do more than offer readers colorful stories. They help us see the way our health is shaped by forces invisible to the untrained eye. Is there ever a good time to have a heart attack? Do you choose the veteran doctor or the rookie?  Do you really need the surgery your doctor recommends? These questions are rife with significance; their impact can be life changing. Addressing them in a style that’s both animated and enlightening, Random Acts of Medicine empowers you to see past the white coat and find out what really makes medicine work—and how it could work better.

Thanks to Doubleday Books for this review copy! Authors Anupam B. Jena and Christopher Worsham have collaborated on a fascinating and eye-opening book at the intersection of health and economics. The book explores the surprising and often counterintuitive ways that medicine works. The authors, both doctors and researchers at Harvard Medical School, use natural experiments—random events that create natural comparisons among people—to reveal the hidden factors that influence our health outcomes.

Jena and Worsham look at medicine from a few different angles, including the role of chance and luck, the power of natural experiments, and the future of healthcare. Jena and Worsham do an excellent job of explaining complex concepts in a way that is easy to understand.

The book is divided into three parts: “The Hidden Side of Medicine,” “The Power of Natural Experiments,” and “The Future of Medicine.” In the first part, Jena and Worsham explore the ways in which chance and luck play a role in our health. They discuss how our birthdate, our zip code, and even our name can all influence our health outcomes.

In the second part of the book, Jena and Worsham introduce the concept of natural experiments. Natural experiments are events that happen outside of a doctor’s control, but which can be used to learn about the effects of different medical treatments or interventions. For example, Jena and Worsham discuss how the introduction of a new drug can be used to study the effects of that drug on a population of patients.

In the third part of the book, Jena and Worsham look at the future of medicine. They discuss how the rise of big data and artificial intelligence is changing the way we understand and treat disease. They also discuss the challenges that we face in making sure that everyone has access to high-quality healthcare.

For example, they show how kids born in the summer are more likely to be diagnosed with ADHD, how marathons can harm your health even if you don’t run, how surgeons and salesmen have similar incentives, and how an annual event made people 30 percent more likely to get COVID-19. The book is full of intriguing stories and insights that challenge our assumptions and make us think differently about medicine and health care.

The book is also written in a clear and engaging style that makes it accessible and enjoyable for anyone interested in learning more about the science and economics of medicine. The authors combine rigorous research with personal anecdotes and humor to illustrate their points and keep the reader hooked. They also offer practical advice on how to make better decisions for ourselves and our loved ones when it comes to our health. One caveat: I felt the book was a bit long. I think it could have been shorter without losing any of the valuable information.

Random Acts of Medicine is an informative read for anyone who wants to understand how medicine really works, and how it could work better. It will make you smarter, healthier, and more informed about one of the most important aspects of our lives. I recommend it to anyone who is interested in learning more about the hidden side of medicine, the power of natural experiments, and the future of healthcare.

Want your own copy? You can pick it up here.

TORNADO OF LIFE by Jay Baruch

August 30, 2022 / Kyle Wendy Skultety / 0 Comments

Stories from the ER: a doctor shows how empathy, creativity, and imagination are the cornerstones of clinical care.

To be an emergency room doctor is to be a professional listener to stories. Each patient presents a story; finding the heart of that story is the doctor’s most critical task. More technology, more tests, and more data won’t work if doctors get the story wrong. Empathy, creativity, and imagination are the cornerstones of clinical care. In Tornado of Life, ER physician Jay Baruch offers a series of short, powerful, and affecting essays that capture the stories of ER patients in all their complexity and messiness.

Patients come to the ER with lives troubled by scales of misfortune that have little to do with disease or injury. ER doctors must be problem-finders before they are problem-solvers. Cheryl, for example, whose story is a chaos narrative of “and this happened, and then that happened, and then, and then and then and then,” tells Baruch she is “stuck in a tornado of life.” What will help her, and what will help Mr. K., who seems like a textbook case of post-combat PTSD but turns out not to be? Baruch describes, among other things, the emergency of loneliness (invoking Chekhov, another doctor-writer); his own (frightening) experience as a patient; the patient who demanded a hug; and emergency medicine during COVID-19. These stories often end without closure or solutions. The patients are discharged into the world. But if they’re lucky, the doctor has listened to their stories as well as treated them.

Thanks to NetGalley and MIT Press for this review copy!

TORNADO OF LIFE is a quick read, filled with short stories about patients presenting to the emergency room and how they provoke the doctor’s thoughts and actions. For example, one of the first patients the author sees (as a brand-new doctor) is a woman, presenting with vague symptoms, but appearing well. It turns out that she may have been abused by her husband, and just needed someone to talk to, and perhaps have someone suggest a course of action for her. Baruch regrets not seeing the patient’s true needs and says that case stayed in his mind for a while. He attributes his lack of communication to his inexperience and explains to the reader why it is important to consider the whole patient, not just what they are telling you. He also says an ER doctor should not judge a patient on how they look when they show up to the ER. Sometimes the most disheveled need the least care, and vice versa.

He tells the story of a patient asking for pain meds; and is unsure if he should prescribe them. He discusses the dilemma of drug-seeking patients and how pain is unmeasurable, unlike a temperature or a heart rate. Baruch says that “do no harm” is a doctor’s first tenet, but when it comes to pain, you may be damned if you do or damned if you don’t. If someone is in real pain, he is obligated to help them. But if a patient is looking for drugs to feed his habit, then prescribing them could harm them as Baruch encourages them to continue their addiction.

Each chapter holds a new patient’s story and the lesson the ER doctor learned from the case. Communication and empathy are a recurring theme, which makes sense. An ER visit is fraught with anxiety, and it can be comforting if a caring physician examines you. Often the doctor has only a few minutes to connect with the patient, which makes getting through the layers of each person’s needs exceedingly difficult. The chapters are stand-alone stories, making the book easy to read in small bites.

Baruch touches on each of those layers in depth, ruminating on how he could have helped some patients better, how some patients helped him learn more about himself, and detailing the psychic struggle that doctors experience daily. Baruch comes across as an extremely caring and empathetic person; I would appreciate his care should I ever need to visit his ER.

The only thing that frustrated me about TORNADO OF LIFE was that I never got closure on any of the patient’s ailments. The author states that in the beginning of the book – there will only be a few details about the ER visit and then the rest of the chapter will be introspection. I found myself wanting to know more about each patient, what their diagnosis was and how they were addressed before they were discharged. I learned to put my dismay aside as I got through each chapter, understanding that the point of each story was Baruch’s rumination and a lesson learned.

This is an unusual book, as the doctor’s thoughts are shared front and center. Most books written by those in the medical field will give a great deal of detail on their patients with a bit of introspection added. TORNADO OF LIFE is the opposite, and the reader needs to take time to digest the deep thoughts Baruch shares. Reading this will give you new respect for ER doctors and all that they handle on a daily basis.

Want to read this book? You can pick up your copy here.

SPARE PARTS by Paul Craddock

April 5, 2022 / Kyle Wendy Skultety / 0 Comments

Paul Craddock’s Spare Parts offers an original look at the history of medicine itself through the rich, compelling, and delightfully macabre story of transplant surgery from ancient times to the present day.

How did an architect help pioneer blood transfusion in the 1660’s?
Why did eighteenth-century dentists buy the live teeth of poor children?
And what role did a sausage skin and an enamel bath play in making kidney transplants a reality?

We think of transplant surgery as one of the medical wonders of the modern world. But transplant surgery is as ancient as the pyramids, with a history more surprising than we might expect. Paul Craddock takes us on a journey – from sixteenth-century skin grafting to contemporary stem cell transplants – uncovering stories of operations performed by unexpected people in unexpected places. Bringing together philosophy, science and cultural history, Spare Parts explores how transplant surgery constantly tested the boundaries between human, animal, and machine, and continues to do so today.
Witty, entertaining, and illuminating, Spare Parts shows us that the history – and future – of transplant surgery is tied up with questions about not only who we are, but also what we are, and what we might become.

Thanks to St. Martin’s Press and NetGalley for this ARC! The subtitle of this book is: The Story of Medicine through the History of Transplant Surgery. There is minimal gore (there are a few exceptions) and a great deal of history. The first chapter starts in the 1500’s and starts out with “Skin” and ends in the 1960’s with “Organs” and “Transplant Future”. The book also includes illustrations that add another dimension to the written word.

I always love when a book piques my interest so much that I Google the subject to learn more. SPARE PARTS does just that. One of the more…interesting… items was an old YouTube video of disembodied parts living outside the body of deceased dogs. The film was made in 1940 and is found under the title of “Experiments in the Revival of Organisms”. The highlight (?) of this film is a disembodied dog head reacting to stimuli as it is kept “alive” by an artificial heart and lungs. Not for the faint of heart.

I was totally unaware of the history behind transplants, so reading this book was quite intriguing. Apparently tooth transplants were all the rage in the late 1600’s, with poor children selling their teeth to be transplanted into the mouths of the wealthy. It was poignant to think that the only items of value that those poor children had were their teeth. The book makes note that they were quite eager to sell their dentition in order to make money so they could eat. I am not sure how satisfying meals were, having to consume their food with minimal or no teeth in their mouth.

The book also discusses blood transfusions between humans and animals, and kidney/heart/organ transplants. There is a great deal of history along with the author’s thoughts on the subjects. SPARE PARTS is written well, in a way that a reader with no medical background will understand. Those with a medical background will enjoy it as well, as the history aspect may add another layer to their knowledge.

I enjoyed reading SPARE PARTS so much, as it taught me more of the historical aspect of transplants and how the practice has evolved over the years. It is always amazing to read about how physicians practiced hundred of years ago, and what they thought about the workings of the human body.

If you are interested in learning more about the unusual history of transplant surgery I definitely recommend this book. Well written and quite interesting!

You can pick up your copy here.

Pill by Robert Bennett

March 28, 2019 / Kyle Wendy Skultety / 0 Comments

Object Lessons is a series of short, beautifully designed books about the hidden lives of ordinary things.

“You are what you eat.”

Never is this truer than when we take medications—from beta blockers and aspirin to Viagra and epidurals— especially psychotropic pills that transform our minds as well as our bodies. Meditating on how modern medicine increasingly measures out human identity not in T. S. Eliot’s proverbial coffee spoons but in 1mg-, 5mg-, or 300mg-doses, Pill traces the uncanny presence of psychiatric pills through science, medicine, autobiography, television, cinema, literature, and popular music. Ultimately, it argues that modern psychopharmacology reveals a brave new world in which human identities—thoughts, emotions, personalities, and selves themselves—are increasingly determined by the extraordinary powers of seemingly ordinary pills.

Object Lessons is published in partnership with an essay series in The Atlantic.

Thanks to NetGalley for this ARC!

This short read was at once chilling and informative. The statistics alone will make you stop to think: are you one of the 5 US adults who uses a drug for a psychiatric problem? Are you on a “cocktail” of drugs to manage your condition? If you are not, certainly someone around you is on psychotropic medication.

The first 5 chapters are reserved for discussions of drugs such as Lithium, Prozac, and Adderall. The last portion describes the author’s personal experiences of manic times, complete with eye-opening photos of what his journal looked like while in the grip of mania (omg!) and when he returned to a more stable state.

As I read on, I became concerned with the writer’s sentiment. I suffer from depression and was quite stable until about a year ago. My medication stopped working and I have been trying different ones, hoping for one to work so I can be happy again. Reading about how many “cocktails” are in use and their failure rate was not encouraging. At one point I needed to put the book aside until I felt prepared to read the rest. After I told myself that this was just one person’s opinion and that there is still hope for me, I returned to the story with a grain of salt. I can equivocally say that my first medication did not alter my personality at all – I was still “me”, just a happier version.

The book shines in its in-depth illustration of just how debilitating mental illness can be, and how the search for the “right” medication can be a struggle. However, I would strongly suggest to the author to check his writing for the word “quotidian”, as the presence of the word on nearly every page grew wearisome. I am sure he would be able to find an acceptable substitute. Otherwise, PILL was an informative and easy read. I learned some new information and have a new respect for those who struggle with trying to find the right medicine so their life will be worth living.

Want your own copy? You can pick it up here.

Influenza by Jeremy Brown

January 22, 2019 / Kyle Wendy Skultety / 0 Comments

On the 100th anniversary of the devastating pandemic of 1918, Jeremy Brown, a veteran ER doctor, explores the troubling, terrifying, and complex history of the flu virus, from the origins of the Great Flu that killed millions, to vexing questions such as: are we prepared for the next epidemic, should you get a flu shot, and how close are we to finding a cure?

While influenza is now often thought of as a common and mild disease, it still kills over 30,000 people in the US each year. Dr. Jeremy Brown, currently Director of Emergency Care Research at the National Institutes of Health, expounds on the flu’s deadly past to solve the mysteries that could protect us from the next outbreak. In Influenza, he talks with leading epidemiologists, policy makers, and the researcher who first sequenced the genetic building blocks of the original 1918 virus to offer both a comprehensive history and a roadmap for understanding what’s to come.
Dr. Brown digs into the discovery and resurrection of the flu virus in the frozen victims of the 1918 epidemic, as well as the bizarre remedies that once treated the disease, such as whiskey and blood-letting. Influenza also breaks down the current dialogue surrounding the disease, explaining the controversy over vaccinations, antiviral drugs like Tamiflu, and the federal government’s role in preparing for pandemic outbreaks. Though 100 years of advancement in medical research and technology have passed since the 1918 disaster, Dr. Brown warns that many of the most vital questions about the flu virus continue to confound even the leading experts.
Influenza is an enlightening and unnerving look at a shapeshifting deadly virus that has been around long before people—and warns us that it may be many more years before we are able to conquer it for good.

Thanks to NetGalley for the ARC!

Yes, this is another book on the influenza pandemic of 1918 – my goal is to read them all. Seriously, it is always good to compare one with the other and possibly learn new information. One new angle with this book is that the author discusses the Tamiflu controversy in detail (I wasn’t aware of the issues behind this drug, and the backstory makes the juxtaposition with the pandemic particularly chilling). Another angle is that this book is not restricted to the 1918 outbreak; there is a discussion of the virus in general, what type of research has been done, and puts forth the probability of when/how another outbreak could be possible.

One of my favorite portions of the book was the story behind the exhumed victims and how the virus was recovered from their bodies. The author’s respect for their sacrifice shines clearly through in this section, which is detailed but not gory. The gore factor is minimal, compared to other books on influenza or diseases in particular.

The fact that the author is a medical doctor means that he’s done his research and can strike the balance between med-speak and conveying his ideas to the general public. The book is very easy to read and eminently understandable. I read this over the course of a few days and it kept me interested throughout. It is always refreshing when an author can take a subject and provide a fresh, relevant look at it.

You can pick up your own copy here.

The Atlas of Disease by Sandra Hempel

December 18, 2018 / Kyle Wendy Skultety / 0 Comments

Behind every disease is a story, a complex narrative woven of multiple threads, from the natural history of the disease, to the tale of its discovery and its place in history.
But what is vital in all of this is how the disease spreads and develops. In The Atlas of Disease, Sandra Hempel reveals how maps have uncovered insightful information about the history of disease, from the seventeenth century plague maps that revealed the radical idea that diseases might be carried and spread by humans, to cholera maps in the 1800s showing the disease was carried by water, right up to the AIDs epidemic in the 1980s and the recent Ebola outbreak.

Crucially, The Atlas of Disease will also explore how cartographic techniques have been used to combat epidemics by revealing previously hidden patterns. These discoveries have changed the course of history, affected human evolution, stimulated advances in medicine and shaped the course of countless lives.

Thanks to NetGalley for granting my wish to access this ARC! For anyone who is interested in the history of disease, this book is a dream come true. The author delves into each disease with a thoughtful manner and straightforward way, using maps of the world to show the spread of each illness. These maps add a new dimension of understanding to the text, and underscore how devastating the spread of disease can be. The trail of germs is traced across the continents for each disease, adding a quiet horror to the author’s words. This alone makes the book worth buying – no other book I’ve read with this subject has illustrations quite like this. Interspersed in the chapters are other bits of artwork, either paintings of people suffering or government posters warning townfolk of the ravages of the flu, yellow fever, measles, and the like. THE ATLAS OF DISEASE stands out head and shoulders among other novels in this genre.

There are 4 sections to the book: airborne, waterborne, insects and animals, and human to human. Each chapter in the section then outlines a disease, from AIDS to Zika. The opening page has the disease name, the causal agent, transmission, symptoms, incidence and deaths, prevalence, prevention, treatment, and global strategy. For example, diptheria’s incidence and deaths statement lets us know that the germ causes around 5,000 cases per year worldwide, with 5-10% cases being fatal. The global strategy notes that there are childhood vaccination programs, but the World Health Organization (WHO) describes it as a “forgotten” disease. On the opposite page there is a painting by Francisco de Goya showing a man holding a child on his lap, supporting his head with his left hand while he probes the child’s mouth with his right. The work is entitled El Lazarillo de Tormes or El Garrotillo (“Diptheria”). When you turn the page you see illustrations of how the illness attacks the lining of the throat, causing the victim to strangle and suffocate.

I can honestly say I have learned more from this book than from many others I’ve read. The writer’s style is straightforward, sharing facts without drama, and extremely easy to comprehend. You won’t need a medical background to appreciate ATLAS. The author’s fascination with these illnesses is clearly portrayed on every page, as well as her depth of research. I cannot say enough superlatives about this book – it is far and away the best work I’ve read this year. If you are a devotee of disease, you will treasure this work forever. And for those of you who are not – please still read this. You will learn, you will be shocked, and you will appreciate the fragility of life.

Pick up your copy here.

Playing the Ponies and Other Medical Mysteries Solved by Stuart B. Mushlin

February 6, 2018 / Kyle Wendy Skultety / 0 Comments

With over forty years of experience as a sought after diagnostician, Dr. Stuart Mushlin has cracked his share of medical mysteries, ones in which there are bigger gambles than playing the ponies at the track. Some of his patients show up with puzzling symptoms, calling for savvy medical detective work. Others seem to present cut-and-dry cases, but they turn out to be suffering from rare or serious conditions.

In Playing the Ponies and Other Medical Mysteries Solved, Dr. Mushlin shares some of the most intriguing cases he has encountered, revealing the twists and turns of each patient’s diagnosis and treatment process. Along the way, he imparts the secrets to his success as a medical detective—not specialized high-tech equipment, but time-honored techniques like closely observing, touching, and listening to patients. He also candidly describes cases where he got things wrong, providing readers with honest insights into both the joys and dilemmas of his job.
Dr. Mushlin does not just treat diseases; he treats people. And this is not just a book about the ailments he diagnosed; it is also about the scared, uncertain, ailing individuals he helped in the process. Filled with real-life medical stories you’ll have to read to believe, Playing the Ponies is both a suspenseful page-turner and a heartfelt reflection on a life spent caring for patients.

Thanks, Rutgers University Press, for this review copy!

This book should be enjoyed most by those in the medical field. It’s a no-frills, straightforward collection of odd cases and the mental acuity needed to solve them. There is minimal gore, yet there is excellent description of the patient and how he is suffering. Each chapter is a new disease process, with the thorough history given, then the doctor’s thought process. Most of the cases have an ending; there are a few where the patient is not seen again or fails to return for a recheck visit.

Some cases are difficult merely because the patient is not forthcoming with complete medical history, where others are truly “zebras” instead of horses (There is a famous statement that notes when you hear hoofbeats, think horses, not zebras). Each case can be read on its own, with no continuity between chapters – great for absorbing a single chapter before bed.

Mushlin notes that he was an English major before he went to medical school, something that has held him in great stead as he examines patients. He notes how important it is to listen to their words as well as the silence between the words. Imagine that – a doctor taking the time to actually listen to their patient’s complaints! Mushlin’s quiet and caring bedside manner shines through on every page, even when he is handling an especially recalcitrant patient he does his best to care for her.

All four of the reviews noted on the back of the book jacket are from medical doctors, and expound on the joy of reading this book. Most of the reviews online by lay people are positive, except for someone who calls the writing wooden, and feels the stories are too short. I feel the reviewer was not familiar with this type of book; namely, a kind that minimizes drama and emphasizes the medicine. Mushlin’s style is plain and full of information. I understood everything he was saying, because I am a veterinary nurse and quite familiar with the workings of the body. In fact, I can say this is one of the few books I have read that gave so much detail on each patient before the diagnosis was discussed. I felt as if I were part of Dr Mushlin’s team with the patient right in front of me.

The only part of the book that I have a complaint about is in the chapter Learning From The Patient. The author notes that they practiced studies in a dog lab, so as to learn about basic physiologic processes. He goes on to note that “…the human body is not the same as a dog’s, humans are much more complex…”. This frustrated me, as I feel that many canine and human diseases are shared, such as diabetes, cancer, Addison’s, and neurologic issues. Each species is a complex being, similar yet different. I took his statement as demeaning to dogs and animals in general. Veterinary medicine is just as complex as human medicine, and requires the same mental and emotional effort to heal those patients. Perhaps if Dr Mushlin spent some time at an emergency veterinary hospital he would understand my feedback.

That concern was the only negative feedback I have for PLAYING THE PONIES – I found it a stimulating and fascinating read; educational without being taxing. Every patient should have a Dr Mushlin caring for him.

Want your own copy? You can pick it up [easyazon_link identifier=”0813570557″ locale=”US” nw=”y” tag=”gimmethatbook-20″]here[/easyazon_link].